Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk.

Numerous observational studies have highlighted associations between mitochondrial dysfunction and schizophrenia (SCZ), yet the causal relationship remains elusive. This study aims to elucidate the causal link between mitochondria-associated proteins and SCZ. We used summary data from a genome-wide association study (GWAS) of 66 mitochondria-associated proteins in 3,301 individuals from Europe, as well as a GWAS on the large, multi-ethnic ancestry of SCZ, involving 76,755 cases and 243,649 controls.

Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis.

Dysregulated lipid metabolism is linked to tumor progression. In this study, we identified Niemann-Pick C1-like 1 (NPC1L1) as a downstream effector of PKM2. In breast cancer cells, PKM2 knockout (KO) enhanced NPC1L1 expression while downregulating peroxisome proliferator-activated receptor α (PPARα) signaling pathway.

The recent advance of PROTACs targeting BCR-ABL for the treatment of chronic myeloid leukemia.

The chronic myeloid leukemia is a malignant hematopoietic disorder in which the BCR-ABL kinase has been identified as the causative protein. The inhibitors targeting BCR-ABL kinase have been extensively employed in clinical management of chronic myeloid leukemia, significantly enhancing survival rates and prognosis for patients. Despite the extensive utilization of 1st to 4th generation BCR-ABL inhibitors in clinical therapy, the emergence of drug-resistant mutations necessitates an urgent quest for novel therapeutic strategies.

The Evaluation of Antibacterial Coatings Against Commonly Found Pathogenic Bacteria in the Environment-Implications for Environmental Safety and Infection Prevention.

Microorganisms, including pathogens that cause skin, respiratory, and urinary tract infections, are widespread in our environment. Despite routine cleaning with bleach and disinfectants, the transmission of pathogens still occurs, leading to potential infectious diseases. This study aimed to determine the antibacterial effect of two coating formulas against common environmental pathogens like , , , , sp.

Eliminating Anisotropy of 7085 Alloy Forgings via Temperature Combination Control During Two-Stage Multi-Directional Forging.

Due to its high mechanical properties and low quench sensitivity, 7085 aluminum alloy is suitable for the aircraft industry. However, large cross-section forgings of 7085 alloy usually have over 40% anisotropy in mechanical behaviors, especially in the vertical direction. In this study, two-stage multi-directional forgings (MDFs) with different temperature combinations, isothermal medium-temperature composite MDF (MC-MDF) and isothermal hot MDF (H-MDF), were applied to 7085 aluminum alloy ingots.