Precise morphology control of all-organic core-shell droplets for synthesis of microencapsulated phase change materials through AC electric fields.

Hypothesis: Complex emulsions usually consist of aqueous phases, like oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w), serving foundational roles in colloid science. Oil-in-oil-oil (o/o/o) emulsions offer new avenues for non-aqueous reagents but face challenges in balancing the forces between multiple organic phases.

Experiments: In this work, we generate o/o/o emulsions by integrating an AC electric field with a double cross-junction microchannel.

Quantitative Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) Analysis of Macular Microvascular Alterations in Bietti Crystalline Dystrophy.

Purpose: Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.

Methods: This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification.

DDO1002, an NRF2-KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response.

Oxidative stress diminishes the functionality of hematopoietic stem cells (HSCs) as age advances, with heightened reactive oxygen species (ROS) levels exacerbating DNA damage, cellular senescence, and hematopoietic impairment. DDO1002, a potent inhibitor of the NRF2-KEAP1 pathway, modulates the expression of antioxidant genes. Yet, the extent to which it mitigates hematopoietic decline post-total body irradiation (TBI) or in the context of aging remains to be elucidated.

Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients.

Background: Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of action, and quick and smooth recovery. However, the pharmacokinetic characteristics of continuous infusions and the correlation between the plasma concentration and the bispectral index (BIS) in elderly patients are still unknown.

Method: In this randomized, controlled study, thirty elderly patients (62-78 years old) undergoing elective gastrointestinal tumor resection were treated with propofol (N = 15) or ciprofol (N = 15) as sedatives during anesthesia.

Development and validation of a risk stratification model for stroke recurrence after acute ischemic stroke in young adults: A nomogram-based, multicenter retrospective study.

Objective: The prevalence of ischemic stroke in young adults has increased dramatically. However, factors associated with prognosis in this cohort have not been well studied. This study primary aimed to construct and validate a nomogram for predicting stroke recurrence and to achieve risk stratification of young adults after acute ischemic stroke (AIS).