Biomarkers.

Background: To elucidate the biological mechanisms underpinning the association between macular Retinal Nerve Fiber Layer (RNFL) thickness and cognitive function in older adults, this study investigates its correlation with brain volume and cortical thickness.

Method: From a community-dwelling prospective cohort, we included 166 non-demented participants aged over 65 years (mean age 75.2 ± 5.

Biomarkers.

Background: Ethnic differences in amyloid-β (Aβ) characteristics and cognitive trajectories should be considered, when designing Aβ-targeted therapies. The clinical effects of co-pathologies of Aβ have not been evaluated extensively across various dementias. We investigated the prevalence of Aβ+ and cognitive trajectories in Koreans and non-Hispanic whites (NHWs) with Alzheimer's clinical syndrome (ACS) and the clinical effects of Aβ+ in other dementias.

Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.

Opioid receptors, a subfamily of G protein-coupled receptors (GPCRs), are key therapeutic targets. In the canonical GPCR activation model, agonist binding is required for receptor-G protein complex formation, while antagonists prevent G protein coupling. However, many GPCRs exhibit basal activity, allowing G protein association without an agonist.

Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea.

The need to understand subjective health has increased during the COVID-19 pandemic, given its substantial impact on lifestyle habits and perceptions. Thus, this study aimed to investigate the trends and association of subjective health with demographic and behavioral factors, primarily focusing on the change when the COVID-19 pandemic emerged. This study used data from the Korea Youth Risk Behavior Web-based Survey, comprising 1,190,468 adolescents aged 12-18 years (female, 48.

Effect of Seed Hydropriming on the Elongation of Plumule and Radicle During the Germination Process and Changes in Enzyme Activity Under Water-Deficient Conditions.

Hydropriming rice seeds effectively improve the germination percentage, shortens the germination period, and promotes seedling growth. The impact of seed hydropriming is to speed up growth under dry soil conditions, thereby avoiding drought damage. This study analyzes the effect of hydropriming on morpho-physiological changes in the water uptake of rice seeds using "Kasalath" and "Nipponbare" under water-deficit conditions.