Advanced Paediatric Life Support: A 25-year journey in Australia.

Over twenty-five years ago the first Advanced Paediatric Life Support (APLS) course was held in Australia. Through the lens of quality culture in educational organisations, we can identify factors which have underpinned the evolution, sustainability and success of this course.

Interrelationships between social exclusion, mental health and wellbeing in adolescents: insights from a national .

Aims: Adolescence is a critical developmental phase during which young people are vulnerable to the experiences of mental ill-health and social exclusion (consisting of various domains including education and employment, housing, finances and social supports and relationships). The aims of this study were to (i) obtain an understanding of the relationships between social exclusion, mental health and wellbeing of young people; and (ii) identify potentially modifiable targets, or population groups that require greater or targeted supports.

Methods: Data were obtained from the Mission Australia 2022 , Australia's largest annual population-wide survey of young people aged 15-19 years ( = 18,800).

mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting.

We investigated mRNA vaccines encoding a membrane-anchored receptor-binding domain (RBD), each a fusion of a variant RBD, the transmembrane (TM) and cytoplasmic tail fragments of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In naive mice, RBD-TM mRNA vaccines against SARS-CoV-2 variants induced strong humoral responses against the target RBD. Multiplex surrogate viral neutralization (sVNT) assays revealed broad neutralizing activity against a range of variant RBDs.