Publications by authors named "S H Togo"

Metastasis is a significant contributor to cancer-related mortality and a critical issue in cancer. Monitoring the changes in circulating tumor cells (CTCs) with metastatic potential is a valuable prognostic and predictive biomarker. CTCs are a rare population in the peripheral blood of patients with cancer.

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Article Synopsis
  • Efficient processing of multichannel biosignals is vital for healthcare and human-machine interaction, but existing methods face challenges in feature extraction, model complexity, and generalization to new data.
  • The proposed solution is a 1D-based deep intra and inter channel (I2C) convolutional neural network that improves feature extraction while reducing the number of parameters needed.
  • The I2C model shows improved accuracy and generalization in experiments conducted on public biosignal databases, demonstrating its effectiveness over traditional methods.
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Article Synopsis
  • - We created a new optical microscope that can simultaneously image both the fluidity and structure of cell membranes to understand cell adhesion better.
  • - In tests, we observed how a giant unilamellar vesicle interacts with a glass surface, revealing areas of membrane fluidity and corresponding adhesion sites in both cancerous and non-cancerous cells.
  • - By manipulating cholesterol and unsaturated lipids, we identified distinct adhesion signatures in cancer cells, suggesting that our microscope could help study membrane properties in various cell types beyond just cancer.
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Cancer organoids have emerged as a valuable tool of three-dimensional (3D) cell cultures to investigate tumor heterogeneity and predict tumor behavior and treatment response. We developed a 3D organotypic culture model of oral squamous cell carcinoma (OSCC) to recapitulate the tumor-stromal interface by co-culturing four cell types, including patient-derived cancer-associated fibroblasts (PD-CAFs). : A stainless-steel ring was used twice to create the horizontal positioning of the cancer stroma (adjoining normal oral mucosa connective tissue) and the OSCC layer (surrounding normal oral mucosa epithelial layer).

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Gum chewing is used in orofacial therapy to improve oral functions, such as a patient's chewing ability, bite force, tongue pressure, and lip closure strength. However, its effects on masseter muscle oxygen dynamics and muscle activity may vary with the hardness and features of the gum base. Therefore, when considering gum chewing for therapeutic purposes, it is essential to select gum of an appropriate hardness.

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