Design, synthesis, and biological evaluation of tetrahydropyrimidine analogue as GSK-3β/Aβ aggregation inhibitor and anti-Alzheimer's agent.

The complex nature of Alzheimer's disease (AD) etiopathology is among the principal hurdles to developing effective anti-Alzheimer agents. Tau pathology and Amyloid-β (Aβ) accumulation are hallmarks and validated therapeutic strategies of AD. GSK-3β is a serine/threonine kinase involved in tau phosphorylation.

Synthesis of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives as potential anti-diabetic and anticancer agents.

In this work, we developed a series of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1,3,5)-trione derivatives a one-pot multicomponent reaction. The structures of the compounds were confirmed using analytical and spectroscopic techniques. Also, the synthesized compounds were screened for their anti-diabetic activity, cytotoxicity and studies.

Intravenous Dexmedetomidine-Ketamine Versus Ketamine-Propofol for Procedural Sedation in Adults Undergoing Short Surgical Procedures: A Randomized Controlled Trial.

Background and objective Moderate to deep sedation is a prerequisite during total intravenous anesthesia for short-duration surgeries, and it can be achieved by using individual drugs or in combination. Our study compared dexmedetomidine-ketamine (DK) versus ketamine-propofol (KP) in terms of sedation, procedural interference, hemodynamics, and incidence of side effects in patients undergoing short surgical procedures. Methods A total of 194 patients scheduled for short-duration elective surgeries were randomly allocated into two groups.

A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline.

A simple, novel, and less cost yellow (Erythrosine) modified pencil graphite electrode (Po-ERY/MGPE) was successfully fabricated via electropolymerization method using cyclic voltammetric techniques. The fabricated Po-ERY/MGPE opted as a sensor for the detection of Adrenaline (ADR) in 0.2 M PBS (7.

Application of radon (Rn) as an environmental tracer in hydrogeological and geological investigations: An overview.

Radon (Rn) is a colourless, odourless, inert, and radioactive noble gas (t = 3.8 days) that emanates from rocks and soils as a result of the alpha decay of its parent, radium (Ra) in the decay series of uranium-238, is the focus of this study. Radon is produced in the crystal lattice of the minerals and emanates out through alpha recoil.