An activity-based synthetic population of Gothenburg, Sweden: Dataset of residents in neighbourhoods.

A synthetic population is a distribution of synthetic agents that replicates the demographic distribution of a real-world population based on census records. This paper presents an end-to-end model to generate a synthetic population of residents in Gothenburg, Sweden, along with activity schedules and mobility patterns for present and past populations. Using a stochastic modelling approach, we describe the model and present its corresponding dataset.

Sentiment and semantic analysis: Urban quality inference using machine learning algorithms.

Sustainable urban transformation requires comprehensive knowledge about the built environment, including people's perceptions, use of sites, and wishes. Qualitative interviews are conducted to understand better people's opinions about a specific topic or location. This study explores the automatization of the interview coding process by investigating how state-of-the-art natural language processing techniques classify sentiment and semantic orientation from interviews transcribed in Swedish.

Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.

Background: Patients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml) experience more complications after noncardiac surgery. Individuals prescribed renin-angiotensin system (RAS) inhibitors for cardiometabolic disease are at particular risk of perioperative myocardial injury and complications. We hypothesised that stopping RAS inhibitors before surgery increases the risk of perioperative myocardial injury, depending on preoperative risk stratified by plasma NT-proBNP concentrations.

Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial.

Background And Aims: Haemodynamic instability is associated with peri-operative myocardial injury, particularly in patients receiving renin-angiotensin system (RAS) inhibitors (angiotensin-converting-enzyme inhibitors/angiotensin II receptor blockers). Whether stopping RAS inhibitors to minimise hypotension, or continuing RAS inhibitors to avoid hypertension, reduces peri-operative myocardial injury remains unclear.

Methods: From 31 July 2017 to 1 October 2021, patients aged ≥60 years undergoing elective non-cardiac surgery were randomly assigned to either discontinue or continue RAS inhibitors prescribed for existing medical conditions in six UK centres.