Publications by authors named "S H Slifer"
Article Synopsis
- A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
- The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
- While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
Article Synopsis
- The study aimed to identify genetic variants that may contribute to neuropathic ocular pain (NOP) by conducting a genome-wide association study (GWAS) involving 329 patients from a Miami Veterans Affairs eye clinic.
- Researchers used the Neuropathic Pain Symptom Inventory modified for the eye to quantify pain severity and analyzed over 13 million SNPs to find associations with NOP.
- The study identified one lead SNP (rs140293404) with significant association to NOP, along with several notable genes, including matrix metalloproteinase-19 and others, suggesting potential genetic factors influencing the development of this condition.
Alzheimer disease (AD) is the most common type of dementia and is estimated to affect 6 million Americans. Risk for AD is multifactorial, including both genetic and environmental risk factors. AD genomic research has generally focused on identification of risk variants.
View Article and Find Full Text PDFBackground: Verbal and visuospatial memory impairments are common to Alzheimer disease and Related Dementias (ADRD), but the patterns of decline in these domains may reflect genetic and lifestyle influences. The latter may be pertinent to populations such as the Amish who have unique lifestyle experiences.
Methods: Our data set included 420 Amish and 401 CERAD individuals.
Article Synopsis
- - The study addresses the issue of limited ancestral diversity in genome-wide association studies (GWAS), which makes it hard to find genetic risk variants in non-European ancestry groups, focusing on Alzheimer's Disease (AD).
- - Researchers analyzed a multi-ancestry GWAS dataset within the Alzheimer's Disease Genetics Consortium (ADGC) involving individuals from various ancestries, identifying 13 shared risk loci and 3 ancestry-specific loci, highlighting the benefits of diverse samples.
- - The findings underscore the importance of including underrepresented populations in genetic research, suggesting that even smaller sample sizes can lead to the discovery of novel genetic variants related to AD and implicating specific biological pathways like amyloid regulation and neuronal development.