[PRACTICAL AND FUNCTIONAL RESEARCH OF THE INTERACTION OF LEVELS OF PUBLIC AUTHORITY IN FEDERAL STATES IN THE CONTEXT OF THE NEW CORONAVIRUS INFECTION (COVID-19) PANDEMIC: ASSESSMENTS AND PROSPECTS].

Unlabelled: The objectives of this research are to explore foreign experience of interaction of various levels of public authority in federal states in the context of the COVID-19 pandemic, to determine the prospects for the development and improvement of the activities of the public authority system in Russia in this part.

Materials And Methods: The regulatory legal acts and the practice of interaction of various levels of public authority during the COVID-19 pandemic in federations (Australia, India, Canada, USA) were research.

Results: It has been established that a dual federal system with strict rules for the distribution of powers and responsibilities between the federation and its regions impedes a coordinated national response in the fight against the COVID-19 pandemic, while various forms of executive federalism serve as the key to successfully countering this threat.

Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide.

Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.

[Chemicals as fire damaging factor].

The article provides an overview of published scientific data about toxic chemical compounds formed during thermal degradation of various materials. In case of fire the complex of physical and chemical factors affect the human, along with injuries, thermal burns of the skin and respiratory tract there is a lack of oxygen in the inspired air and the impact of thermal degradation products. The greatest number of deaths in.

[Modern approaches to the formation of antidote stocks at medical institutions in Russia and foreign countries].

This article analyses the approaches to the formation of specific treatment of acute poisoning in the various countries. The authors present a systematic review of scientific publications about the formation of reserves of antidote agents at medical institutions of the Russian Federation, the US, Canada, France, Spain, Greece, Norway, Czech Republic, Taiwan and Poland. A search for a variety of databases, as well as by reviewing reference lists of publications on the subject of "stockpiling antidote means".

[The strategy of emergency aid to patients with botulism].

This clinical observation demonstrates difficulty of differential diagnostics of botulism in a patient suspected to have acute pancreatitis and admitted to a multifield medical institution. Difficulties of interpretation of urgent clinical and instrumental examination are discussed. The therapeutic strategy is described.