Publications by authors named "S H Roy-Choudhury"
The heterogeneous form of malignancy in the myeloid lineage of normal hematopoietic stem cells (HSCs) is characterized as acute myeloid leukemia (AML). The t(9;11) reciprocal translocation (p22;q23) generates MLL-AF9 oncogene, which results in myeloid-based monoblastic AML with frequent relapse and poor survival. MLL-AF9 binds with the C-Myb promoter and regulates AML onset, maintenance, and survival.
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- Acute myeloid leukemia (AML) presents challenges due to the presence of dysfunctional natural killer (NK) cells, which are affected by the lack of essential receptors and the action of the polycomb protein EzH2.
- A new strategy involves engineering CD56 NK cells by delivering a plasmid that suppresses EzH2 using chitosan nanoparticles, allowing for improved NK cell function against AML.
- In experimental models, this approach led to reduced leukemia stem cell populations and increased NK cell activity, highlighting its potential as an effective and safer method for AML immunotherapy.
Desiccation tolerance is a complex biological phenomenon that allows certain plants to survive extreme dehydration and revive upon rehydration. Although significant progress has been made in understanding the physiological and molecular mechanisms involved in desiccation tolerance, recovery mechanisms after prolonged desiccation periods are enigmatic. Combining physiological, biochemical, transcriptomic and metabolomic approaches, we investigated the role of prolonged desiccation on recovery of Selaginella bryopteris.
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- The ETCHED study aims to explore how negative factors during pregnancy and early childhood contribute to obesity and metabolic issues in minority groups, particularly American Indian/Alaska Native and Hispanic populations.
- This longitudinal study involves monitoring pregnant women and their children over 18 years, collecting data on health history, lifestyle, and biological samples to assess the risk factors for obesity.
- Multiple check-ups will occur at various stages of the child’s development, with a focus on comprehensive health assessments and environmental influences, using medical records for additional context.