Amphiphilic Chlorin-β-cyclodextrin Conjugates in Photo-Triggered Drug Delivery: The Role of Aggregation.

Conjugates of chlorins with β-cyclodextrin connected either directly or via a flexible linker were prepared. In aqueous medium these amphiphilic conjugates were photostable, produced singlet oxygen at a rate similar to clinically used temoporfin and formed irregular nanoparticles via aggregation. Successful loading with the chemotherapeutic drug tamoxifen was evidenced in solution by the UV-Vis spectral changes and dynamic light scattering profiles.

IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia.

There is growing evidence that high basal cortisol levels and systemic inflammation independently contribute to cognitive decline among older people without dementia. The present cross-sectional study examined (a) the potential synergistic effect of cortisol levels and systemic inflammation on executive function and (b) whether this effect is more prominent among older people with mild cognitive impairment (MCI). A sub-sample of 99 patients with MCI and 84 older people without cognitive impairment (CNI) (aged 73.

Design and Implementation of a Low-Cost Chlorophyll Content Meter.

Chlorophyll meters are portable devices used to assess and improve plants' nitrogen management and to help farmers in the determination of the health condition of plants through leaf greenness measurements. These optical electronic instruments can provide an assessment of chlorophyll content by measuring the light passing through a leaf or by measuring the light radiation reflected from its surface. However, independently of the main principle of operation and use (e.

Experimental Assessment of Common Crucial Factors That Affect LoRaWAN Performance on Suburban and Rural Area Deployments.

LoRaWAN networks might be a technology that could facilitate extreme energy-efficient operation while offering great capacity for suburban and rural area deployment, but this can be a challenging task for a network administrator. Constraints that deform the trade-off triangle of coverage, scalability and energy efficiency need to be overcome. The scope of this study is to review the limitations of the LoRaWAN protocol in order to summarize and assess the crucial factors that affect communication performance, related to data rate allocation, bidirectional traffic and radio spectrum utilization.