BPDE induces ferroptosis in hippocampal neurons through ACSL3 suppression.

Benzo(a)pyrene (B[a]P) and its ultimate active metabolite, benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), are known to have neurotoxic effects that can damage hippocampal neurons and cause cognitive impairments. Ferroptosis, a form of programmed cell death distinct from apoptosis, is associated with multiple neurodegenerative conditions. Recently, we have found that BPDE triggers ferroptosis in hippocampal neurons, though the underlying molecular mechanism remains unclear.

Brain-wide neuronal circuit connectome of human glioblastoma.

Glioblastoma (GBM) infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression. Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic. The extent of GBM integration into the brain-wide neuronal circuitry remains unclear.

Optimizing natural human-derived decellularized tissue materials for periodontal bone defect repair.

Periodontal disease is a major contributor to tooth loss worldwide in adults. Particularly, periodontal bone defect is a common clinical condition, yet current therapeutic strategies exhibit limited effectiveness. Recently, natural bone graft materials have attracted considerable interest for enhancing bone defect repair due to their superior biocompatibility and osteogenic capabilities.

Ultrafast Synthesis of Nanoscale Metal Borides for Efficient Hydrogen Evolution.

Nanoscale metal borides, with exceptional physicochemical properties, have been attracted widespread attention. However, traditional synthesis methods of metal borides often lead to surface coking and large particle sizes. Herein, we have employed a flash Joule heating (FJH) technique to enable the ultrafast synthesis of metal boride nanomaterials.

QOT: Quantized Optimal Transport for sample-level distance matrix in single-cell omics.

Single-cell technologies have enabled the high-dimensional characterization of cell populations at an unprecedented scale. The innate complexity and increasing volume of data pose significant computational and analytical challenges, especially in comparative studies delineating cellular architectures across various biological conditions (i.e.