Publications by authors named "S H Lincoln"
: Cutaneous infections of fungal and bacterial origins are common. An accurate diagnosis-especially concerning pathogens that are difficult to isolate on culture-can be achieved using molecular methods (PCR) with a short turnaround time. : We reviewed records of skin specimens (superficial scrapings) submitted by dermatologists across the United States with a clinically suspected dermatitis.
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- - Onychomycosis is a tough fungal nail infection that can lead to further complications, prompting the need for accurate pathogen identification through testing to enhance treatment effectiveness.
- - A study analyzing over 710,000 patient records from 2015-2024 utilized PCR testing, revealing a wider range of pathogens than previously known, particularly showing that non-dermatophyte molds and yeasts are significant in female patients and older adults.
- - The use of advanced molecular diagnostics allows for quicker and more precise identification of the fungi causing onychomycosis, which can lead to better treatment choices and improved healthcare outcomes.
Introduction: There is an increasing number of reports of infections. This species is usually poorly responsive to terbinafine.
Areas Covered: A literature search was conducted in May 2024.
Article Synopsis
- There is a global rise in antifungal-resistant dermatophytosis, particularly due to mutations in the SQLE gene, affecting treatments with terbinafine.
- A study analyzed 62,056 toenail samples over 18 months, finding significant increases in SQLE mutations, particularly the Phe397Leu and Phe415Ser substitutions, in onychomycosis patients.
- The findings suggest that older individuals are at a greater risk for infections, and the actual prevalence of SQLE mutations might be underestimated among affected patients.
Curcumin is a medicinal agent that exhibits anti-cancer and anti-Alzheimer's disease properties. It has a keto-enol moiety that gives rise to many of its chemical properties including metal complexation and acid-base equilibria. A previous study has shown that keto-enol tautomerization at this moiety is implicated in the anti-Alzheimer's disease effect of curcumin, highlighting the importance of this process.
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