Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway.

Objective: Neuronal damage is criminal to cognitive dysfunction, closely related to endoplasmic reticulum stress (ERS). However, due to the pathogenesis of endotoxin-induced long-term cognitive dysfunction is not fully clarified, there is still a lack of effective treatment. This study was conducted to explore the protective effects and mechanism of rosmarinic acid (RA) against ERS in endotoxin-induced cognitive dysfunction in mice and neuronal injury in cells.

Enhancing CO Oversaturation in the Confined Water Enables Superior Gas Selectivity of 2D Membranes.

Due to the global demands on carbon neutralization, CO separation membranes, particularly those based on two-dimensional (2D) materials, have attracted increasing attention. However, recent works have focused on the chemical decoration of membranes to realize the selective transport, leading to the compromised stability in the presence of moisture. Herein, we develop a series of 2D capillaries based on layered double hydroxide (LDH), graphene oxide, and vermiculite to enhance the oversaturation of CO in the confined water for promoting the membrane permselectivity.

Progressive Bounded Error Piecewise Linear Approximation with Resolution Reduction for Time Series Data Compression.

Today, huge amounts of time series data are sensed continuously by AIoT devices, transmitted to edge nodes, and to data centers. It costs a lot of energy to transmit these data, store them, and process them. Data compression technologies are commonly used to reduce the data size and thus save energy.

Pt@ZnCoO Microspheres as Peroxidase Mimics: Enhanced Catalytic Activity and Application for L-Cysteine Detection.

Compared to natural enzymes, the development of efficient artificial simulated enzymes, such as those based on bimetallic materials with high catalytic activity and good stability, is an important way until now. Herein, we employed ZnCoO microspheres as carriers to synthesize Pt-doped composites with different amounts using a one-pot method. The morphology and structure of the synthesized materials were characterized using XRD, SEM, BET, FT-IR, XPS, and Zeta potential techniques.

Quantitative evaluation of two-way referral policies based on PMC index model.

Objective: Perfect policy system support is the key to effective work, and policy evaluation can provide theoretical basis for policy revision. This study aims to quantitatively evaluate the two-way referral policy in China and thus improve the policy system of two-way referral.

Methods: This research focuses on 14 two-way referral policies published from 2007 to 2021.