Publications by authors named "S H Kleinman"
Background: Storage of packed red blood cells (RBCs) for transfusion leads to biochemical and morphological changes, increasing hemolysis risk. Urate levels in blood bags at donation contribute to the molecular heterogeneity and hemolytic propensity of stored RBCs. However, studies to date have been underpowered to investigate at scale the contribution of donor demographics and genetics to the heterogeneity in urate levels across donations.
View Article and Find Full Text PDFBackground: While artificial intelligence has significantly impacted medicine, the application of large language models (LLMs) in oral and maxillofacial surgery (OMS) remains underexplored.
Purpose: This study aimed to measure and compare the accuracy of 4 leading LLMs on OMS board examination questions and to identify specific areas for improvement.
Study Design, Setting, And Sample: An in-silico cross-sectional study was conducted to evaluate 4 artificial intelligence chatbots on 714 OMS board examination questions.
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. However, the genetic underpinnings of RBC metabolic heterogeneity and extravascular hemolysis at population scale are incompletely understood. Based on the breeding of 8 founder strains with extreme genetic diversity, the Jackson laboratory diversity outbred population can capture the impact of genetic heterogeneity in like fashion to population-based studies.
View Article and Find Full Text PDFIncreasing global life expectancy motivates investigations of molecular mechanisms of aging and age-related diseases. This study examines age-associated changes in red blood cells (RBCs), the most numerous host cell in humans. Four cohorts, including healthy individuals and patients with sickle cell disease, were analyzed to define age-dependent changes in RBC metabolism.
View Article and Find Full Text PDFArticle Synopsis
- Cerebral amyloid angiopathy (CAA) is a brain disorder caused by the accumulation of beta-amyloid in small blood vessels, leading to increased risk of bleeding in the brain and associated neurocognitive decline.
- It often appears with age, frequently coexists with Alzheimer's Disease, and can result in significant health issues like spontaneous intracerebral hemorrhage and progressive dementia.
- Recent studies suggest a potential link between blood transfusions and the transmission of CAA, raising concerns about public health and the need for further research on whether CAA can be transmitted through blood, alongside its implications for screening practices.