Publications by authors named "S H Grieve"
Background: Accurate measurements of flow and ventricular volume and function are critical for clinical decision-making in cardiovascular medicine. Cardiac magnetic resonance (CMR) is the current gold standard for ventricular functional evaluation but is relatively expensive and time-consuming, thus limiting the scale of clinical applications. New volumetric acquisition techniques, such as four-dimensional flow (4D-flow) and three-dimensional volumetric cine (3D-cine) MRI, could potentially reduce acquisition time without loss in accuracy; however, this has not been formally tested on a large scale.
View Article and Find Full Text PDFBackground And Aims: Myeloperoxidase (MPO) plays a critical role in the innate immune response and has been suggested to be a surrogate marker of oxidative stress and inflammation, with elevated levels implicated in cardiovascular diseases, such as atherosclerosis and heart failure, as well as in conditions like rheumatoid arthritis and cancer. While MPO is well-known in leukocytes, its expression and function in human endothelial cells remain unclear. This study investigates MPO expression in patient-derived endothelial colony-forming cells (ECFCs) and its potential association with CAD and mitochondrial function.
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- The study explores the role of inflammatory cytokines and receptors—specifically TRAIL, IL-18, and OPG—in predicting atherosclerotic coronary artery disease (CAD), especially when traditional risk factors are absent.
- It involved analyzing serum biomarker levels from 993 participants to see how these markers correlated with the severity of CAD as determined by CT scans.
- Although some associations were found between these inflammatory markers and CAD scores, they did not remain significant when adjusted for other risk factors like age, sex, and family history, indicating they may not be reliable standalone predictors of CAD.
Article Synopsis
- - Preclinical studies show that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can help repair injured hearts, with multiple clinical trials underway.
- - Ventricular arrhythmias (EAs) can occur after injecting PSC-CMs into the heart, linked to cellular diversity within the transplanted cells, particularly arrhythmogenic subpopulations like atrial and pacemaker-like cardiomyocytes.
- - Identifying specific surface markers may help differentiate risky PSC-CMs from safer ones, and both drug treatments and other interventions can help manage or eliminate these arrhythmias in the experimental model used.
The CSANZ/RANZCR Position Statement on Cardiac Magnetic Resonance Imaging (CMRI) is intended to support and foster the provision of quality, safe CMRI services in Australia and New Zealand. This document specifically pertains to CMRI in adults, as distinct from general vascular MRI or paediatric imaging, and provides certification and recertification requirements.
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