Building epsilon near zero materials from layered uniaxial metamaterials.

Recently, there has been an explosion of activity in the fields of optics and photonics with the advent of fabrication techniques which enable the design of metamaterials which possess properties not encountered in the natural world. In this work, we are concerned with zero permittivity materials and a new scheme to design metamaterials for which all components of the dielectric tensor are approximately zero. Our approach involves the alternate layering of many, very thin, slices of two constituent metamaterials, a uniaxial layered medium and a uniaxial nanowire array.

Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency.

Background: Multiple Sulfatase Deficiency (MSD) is a rare inherited lysosomal storage disorder characterized by loss of function mutations in the SUMF1 gene that manifests as a severe pediatric neurological disease. There are no available targeted therapies for MSD.

Methods: We engineered a viral vector (AAV9/SUMF1) to deliver working copies of the SUMF1 gene and tested the vector in Sumf1 knock out mice that generally display a median lifespan of 10 days.

RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining.

RecQ helicases, highly conserved proteins with pivotal roles in DNA replication, DNA repair and homologous recombination, are crucial for maintaining genomic integrity. Mutations in RECQL4 have been associated with various human diseases, including Rothmund-Thomson syndrome. RECQL4 is involved in regulating major DNA repair pathways, such as homologous recombination and nonhomologous end joining (NHEJ).

Medication Use Quality and Safety in Older Adults: 2023 Update.

Improving the quality of medication use and medication safety are important priorities for healthcare providers who care for older adults. The objective of this article was to identify four exemplary articles with this focus in 2023. We selected high-quality studies that advanced this field of research.

A Qualitative Descriptive Study of Rural Primary Healthcare Professionals' Capacity for Disaster Health Management Before and During the COVID-19 Pandemic.

Introduction: Rural areas face additional challenges in preventing, preparing for, responding to, and recovering from disasters. This study aimed to understand how rural primary healthcare professionals (PHCPs) perceive their roles, involvement, and capacity in disaster health management.

Methods: For this qualitative descriptive research, semi-structured interviews were carried out with convenience and purposive samples of rural PHCPs before and during the COVID-19 pandemic.