Association Between Body Fat Percentage and Urinary Flow Rate in US Adults: Analysis of the National Health and Nutrition Examination Survey 2011-2018.

To assess the relationship between total body fat percentage(TBFP), trunk fat percentage(TFP), and urinary flow rate(UFR).We stratified by age and sex and hypothesize that TBFP and TFP are negatively associated with UFR across all groups.The study utilized data from the National Health and Nutrition Examination Survey (NHANES), which includes a series of nationally representative cross-sectional surveys.

Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production.

Mitochondrial homeostasis plays a major role in the progression of chronic inflammatory bone loss which has a complex pathogenesis with unsatisfactory therapeutic efficiency. Recently, melatonin has been shown to recipient mitochondrial function and bone formation. However, the effects and underlying molecular mechanism of melatonin in chronic inflammatory bone loss remain unclear.

Palladium-Catalyzed and Photoinduced Site-Selective Alkynylation and Oxidation of the Remote C(sp)-H.

A general and efficient method for the direct alkynylation and oxidation of remote C(sp)-H bonds under photoirradiation is described. In this reaction, the Pd catalyst acts as both a photocatalyst to generate the nitrogen radical and a cross-coupling catalyst with a terminal alkyne. Attractive features of this system include good functional group tolerance, scalability, convenient reagents, and an operating system.

Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation.

Isocyanic acid, as a reactive metabolite synthesized by the enzyme LACC1, can carbamoylate the ε-amino group of lysine residues in proteins. However, the role of isocyanic acid in inflammatory response remains elusive. Herein, we reveal that lipopolysaccharide stimulation increases LACC1-dependent isocyanic acid production, which attenuates inflammation by limiting the NLRP3 inflammasome activation in macrophages primed with lipopolysaccharide for 8 hours.

Characteristics and Prognosis of Patients With Non-Syndromic Sensorineural Hearing Loss Associated With Myo15a Mutations.

Objective: This study aims to investigate the characteristics of hearing loss associated with MYO15A mutations and to analyze the longitudinal prognosis over a 4-year period using different treatment modalities, including cochlear implants (CIs), hearing aids (HAs), and conservative management.

Study Design: A retrospective case review.

Setting: A tertiary referral center.