Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic nasopharyngeal carcinoma: a randomised, open-label, phase 2 trial.

Background: Vascular endothelial growth factor (VEGF) is overexpressed in nasopharyngeal carcinoma and suppresses the anti-tumour immune response. Previous studies have shown that adding anti-VEGF treatment to PD-1 inhibition treatment strategies improves tumour response. We aimed to compare the efficacy of pembrolizumab, a PD-1 inhibitor, with or without bevacizumab, a VEGF inhibitor, in nasopharyngeal carcinoma.

Review - Insect farming for food and feed in the Global South: Focus on black soldier fly production.

Clear differences exist between the Global South and the Global North with respect to economic development. The majority of small and medium-sized insect production farms are located in Africa, Asia, and Latin America, which face challenges to food production and organic waste management in general. These regions have a long history of insect use, as well as environmental advantages, making production of insects in general - and the black soldier fly in particular - a promising option for sustainable food production and organic waste management.

Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes.

Nanoplastics (NPs), plastic particles ranging from 1-1000 nm, form through weathering and are considered more hazardous than larger plastics due to their ability to penetrate cell barriers and be internalised by biological systems. Most research on NPs has focused on animal models, examining effects on the brain, lungs, and gastrointestinal tract. To enhance physiological relevance, this study investigated the impact of NPs on human cardiomyocytes (CMs) derived from human embryonic stem cells (hESCs).

Race and Clinical Outcomes in Hormone Receptor-Positive, HER2-Negative, Node-Positive Breast Cancer in the Randomized RxPONDER Trial.

Background: The phase III RxPONDER trial has impacted treatment for node-positive(1-3), hormone receptor-positive, HER2-negative breast cancer with 21-gene recurrence score (RS) ≤ 25. We investigated how these findings apply to different racial and ethnic groups within the trial.

Methods: The trial randomized women to endocrine therapy (ET) or to chemotherapy plus ET.