Publications by authors named "S H Chandler"

Several wildlife species exhibit marked spatial variation in toxicologically relevant tissue concentrations of mercury across the Aleutian Islands of Alaska, most notably the endangered Steller sea lion (Eumetopias jubatus). To unravel potential environmental and trophic pathways driving mercury variation in this species of concern, we investigated spatiotemporal and ecological patterns in total mercury concentrations and stable isotope ratios of carbon and nitrogen from muscle tissues of twelve mid-trophic level prey species of the region (n = 1461). Dividing samples into island groups explained biogeochemical variation better than larger spatial resolutions, with Amchitka Pass and Buldir Pass acting as strong geographic break points.

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Background: There is a growing expectation that neurodivergent young people, such as those with diagnoses of attention-deficit/hyperactivity disorder (ADHD) and/or autism, should play a central role in shaping research on neurodevelopmental conditions. However, currently, their involvement is typically limited to arms-length advice. To address this, the (RE-STAR) programme has co-developed a framework for deepening the involvement of neurodivergent participants in translational research.

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A woman in her 20s presented with nephrotic syndrome and hyperemesis in early pregnancy. Pertinent initial investigations revealed a severe acute kidney injury, a serum albumin of 19 g/L, a random protein creatinine ratio of 800 g/mol and microscopic haematuria. All immunological and infection serology testing including anti-glomerular basement membrane (anti-GBM; ELISA) were negative.

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Article Synopsis
  • Small-molecule degraders can effectively target and degrade disease-driving proteins, offering a new approach for treating previously untreatable conditions.
  • Researchers used cryo-EM to observe how the degrader MZ1 helps position the Brd4 protein for ubiquitination by the UBE2R1 enzyme, leading to its degradation.
  • The study identifies specific lysines on Brd4 that are prone to ubiquitination and suggests a flexible model for how degrader-induced targets could be modified for better drug development.
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