Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential.

Aberrant gene expression due to dysfunction in proteins involved in transcriptional regulation is a hallmark of tumor development. Indeed, targeting transcriptional regulators represents an emerging approach in cancer therapeutics. Lens epithelium-derived growth factor (LEDGF/p75, PSIP1) is a co-transcriptional activator that tethers several proteins to the chromatin.

Late Holocene cooling drove drastic decreases in cladoceran diversity in a subarctic lake.

Subarctic lakes are sentinels of climate change, showing responses in their physical, chemical, and biological properties. However, climate-induced changes in invertebrate diversity and their underlying mechanisms are not fully understood. We explored the relationship between past climate change and taxonomic composition of subfossil cladocerans in a subarctic lake during the last ca.

Liming-induced taxonomic homogenization of chironomid assemblages in Scandinavian lakes as unraveled by paleolimnological reconstructions.

In the 1980s, liming became a large-scale, governmentally supported restoration program implemented by many countries to mitigate the effects of acidification of freshwaters. Despite some 50 years of liming of thousands of lakes and streams, its efficacy remains largely debated. This study is the first of its kind to use paleolimnological reconstructions using both subfossil chironomid assemblages and their carbon stable isotopic composition to compare the ecological trajectories of limed and control (unlimed) lakes over the last 100 years in order to unravel the effects of liming on Scandinavian lakes.

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia.

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Current intensified therapeutic protocols coincide with severe side effects, and no salvage therapy is available for primary therapy-resistant or relapsed patients. This highlights the need to identify new therapeutic targets in T-ALL.