Enhanced Fe═O Generation via Peroxymonosulfate Activation by an Edge-Site Engineered Single-Atom Iron Catalyst.

As an oxidant, the ferryl-oxo complex (Fe═O) offers excellent reactivity and selectivity for degrading recalcitrant organic contaminants. However, enhancing Fe═O generation on heterogeneous surfaces remains challenging because the underlying formation mechanism is poorly understood. This study introduces edge defects onto a single-atom Fe catalyst (FeNC-edge) to promote Fe═O generation via peroxymonosulfate (PMS) activation.

Atomic-level Ru-Ir mixing in rutile-type (RuIr)O for efficient and durable oxygen evolution catalysis.

The success of proton exchange membrane water electrolysis (PEMWE) depends on active and robust electrocatalysts to facilitate oxygen evolution reaction (OER). Heteroatom-doped-RuO has emerged as a promising electrocatalysts because heteroatoms suppress lattice oxygen participation in the OER, thereby preventing the destabilization of surface Ru and catalyst degradation. However, identifying suitable heteroatoms and achieving their atomic-scale coupling with Ru atoms are nontrivial tasks.

[Multi-professional Clearing in a Model Project based on § 64b SGB V by the Example of Geriatric Psychiatry].

As part of the largest model project in Germany in accordance with § 64b SGB V at the Pfalzklinikum, a clearing concept was developed in the Clinic for Geriatric Psychiatry to ensure rapid and adequate diagnosis and effective referral to the further treatment setting. Retrospective data of all clearing cases from the first year are presented. In addition to demographic data and treatment diagnoses, the distribution of patients across settings providing further treatment is presented.

Trends in use of tobacco and cannabis across different alcohol consumption levels in the United States, 2010-19.

Aims: People often drink alcohol and use other substances concurrently, increasing the risk of adverse health outcomes. Our aims were to: (i) assess temporal trends in tobacco and/or cannabis use by varying alcohol consumption levels and (ii) identify associated factors of polysubstance use in high-risk alcohol users.

Methods: We conducted a repeated cross-sectional study combining 2010-19 U.

eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress.

Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational reprogramming. However, transcriptional regulation of mitochondrial homeostasis by eIF2α phosphorylation during ER stress is not fully understood. Here, we report that the eIF2α phosphorylation-activating transcription factor 4 (ATF4) axis is required for the expression of multiple transcription factors, including nuclear factor erythroid 2-related factor 2 and its target genes responsible for mitochondrial homeostasis during ER stress.