Biomarkers.

Background: Understanding the genetic etiology of Alzheimer's disease (AD) has been a major focus of research in neurodegenerative diseases. Amid the three common allelic variants of the apolipoprotein E (APOE) gene in humans, called APOE ε2, ε3 and ε4, the ε4 allele is the most common genetic risk factor for late-onset AD, being found in 20% of the world population.

Method: We used Event-Related Potentials (ERP) and Event-Related Spectral Perturbation (ERSP) as features for classification of apolipoprotein E ϵ4 (APOE ε4) allele carriers in AD patients and healthy controls.

Oral pemphigus vulgaris diagnostic characteristics and treatment: a systematic review.

Pemphigus vulgaris (PV) is a rare, potentially fatal, immune-mediated chronic disease characterized by the presence of bullous intraepithelial lesions on mucous membranes and skin. This study aimed to perform a systematic literature review covering PV clinical and histopathological aspects and treatment. The literature searches were carried out in the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases.

Comparative Analysis of Machine Learning Techniques for Identifying Multiple Force Systems from Accelerometer Measurements.

The knowledge of the forces acting on a structure enables, among many other factors, assessments of whether the component's useful life is compromised by the current machine condition. In many cases, a direct measurement of those forces becomes unfeasible, and an inverse problem must be solved. Among the solutions developed, machine learning techniques have stood out as powerful predictive tools increasingly applied to engineering problem-solving.

Methanolic Extract of (Rhizophoraceae) Leaves: Phytochemical Characterization and Anthelmintic Evaluation against .

is commonly used in traditional medicine to treat infections, reduce inflammation, and promote healing. This study aimed to analyze the phytochemical profile of the methanolic extract of leaves (MELRm) and evaluate its in vitro schistosomicidal activity against as well as its cytotoxicity. Plant material was collected in Itamaracá City, Pernambuco, Brazil.

Antimicrobial and antibiofilm properties of procyanidins: potential for clinical and biotechnological applications.

Procyanidins (PCs) have emerged as agents with potential antimicrobial and antibiofilm activities, although their mechanisms of action and structure-activity relationships remain poorly understood. This review assessed the potential mechanisms of action and applications of these compounds to explore these aspects. Studies on the antimicrobial properties of PCs suggest that they are involved in osmotic imbalance, DNA interactions and metabolic disruption.