Publications by authors named "S Guzy"

Article Synopsis
  • - Vitamin D insufficiency and deficiency are common in chronic kidney disease (CKD) patients, prompting a study to create a pharmacokinetic model for oral cholecalciferol (VitD) and its metabolites in this population.
  • - The study involved 29 CKD patients who were given a single dose of oral VitD, using nonlinear mixed effects modeling to analyze how the drug and its metabolites are processed in the body.
  • - The results indicate that personalized dosing strategies of 600 to 1000 I.U. of VitD per day may be ideal for reaching target 25-hydroxyvitamin D levels, potentially improving treatment for CKD patients.
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Article Synopsis
  • Breakthrough bleeding (BTB) is a common side effect of hormonal contraceptives, particularly combined oral contraceptives (COCs), and can affect user adherence.
  • A model-based meta-analysis was conducted using data from 25 studies to investigate the dose-response relationship of different progestin/ethinyl estradiol (EE) combinations and their effects on BTB.
  • Results indicate that BTB increases when starting COCs but generally returns to baseline within 3 months, especially at higher EE doses; understanding these relationships can aid in optimizing COC treatment regimens.
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Patent ductus arteriosus (PDA) is a blood vessel that critically supports fetal circulation. The ductus naturally closes within a few days after birth. However, it can stay open in premature neonates for an extended period of time, which is associated with increased mortality and various co-morbidities.

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Coronavirus Disease 2019 (COVID-19) causes a wide range of symptoms, including death. As persons recover, some continue to experience symptoms described as Post-Acute COVID-19 Syndrome (PACS). The objectives of this study were to measure the efficacy of Formula C™, a cannabidiol (CBD)-rich, whole-flower terpene-rich preparation in managing PACS symptoms.

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