Publications by authors named "S Gurunathan"
Introduction/aims: Claims-based analyses have demonstrated high medical costs associated with myasthenia gravis (MG). We examined the economic burden of MG from the perspective of affected people and their families.
Methods: The Muscular Dystrophy Association developed and conducted an online survey of people with MG and their caregivers between October 26 and December 6, 2021.
Induction of broad, durable immune responses is a challenge in HIV vaccine development. HVTN 100 Part A administered subtype C-containing ALVAC-HIV at months 0 and 1, and ALVAC-HIV with bivalent subtype C gp120/MF59 at months 3, 6 and 12. As IgG binding antibody and T-cell responses were similar or greater at month 12.
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- Metabolic dysfunction-associated Fatty Liver Disease (MAFLD) has become a leading cardiometabolic condition, and the transcriptional co-regulator FOG2 plays a key role in regulating liver lipid metabolism.
- A specific genetic variant of FOG2 (rs28374544) found mainly in individuals of African descent is linked to liver damage and cirrhosis, and analysis both in vitro and genomically suggests it influences the mTORC1 pathway.
- The study indicates that FOG2 may promote MAFLD through mechanisms such as increased lipid production and accumulation, shedding light on its role in the disease's underlying molecular processes.
Introduction: As the inflammatory bowel disease (IBD) patient population is aging, the prevalence of polypharmacy is rising. However, data exploring the prevalence, risk factors, and clinical outcomes associated with polypharmacy among older adults with IBD are limited. The aim of the study is to determine (i) prevalence of polypharmacy (≥5 medications) and potentially inappropriate medication (PIM) utilization in older adults with IBD, (ii) changes in medications over time, (iii) predictors of polypharmacy, and (iv) the impact of polypharmacy/PIMs on 1-year hospitalization rates.
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- The study investigates the immune response to HSV-2 reactivation by examining T cells in skin biopsies and blood samples before and after vaccination with an HSV-2 candidate vaccine (HSV529).
- After the first vaccine dose, there was a notable increase in HSV-2-specific CD4+ T cell sequences from blood that made their way into the skin, indicating a successful immune memory response.
- Unique T cell clones were identified in the skin that weren't found in the blood, suggesting that the skin has a distinct immune profile, and highlights the importance of studying tissue-specific immunity in vaccine responses.