New perspectives of biological therapy for severe asthma in adults and adolescents.

Severe asthma is associated with increased morbidity, mortality, healthcare costs and impaired quality of life. Asthma is no longer considered as a single entity but as a heterogeneous disease with different clinical presentations (phenotypes) and variable underlying mechanistic biological pathways (endotypes). Two different endotypes are based on the inflammatory Type 2 T-helper response: T2-high and T2-low.

The exogenous application of AtPGLR, an endo-polygalacturonase, triggers pollen tube burst and repair.

Plant cell wall remodeling plays a key role in the control of cell elongation and differentiation. In particular, fine-tuning of the degree of methylesterification of pectins was previously reported to control developmental processes as diverse as pollen germination, pollen tube elongation, emergence of primordia or elongation of dark-grown hypocotyls. However, how pectin degradation can modulate plant development has remained elusive.

Successful home respiratory polygraphy to investigate sleep-disordered breathing in children.

Objective: Sleep-disordered breathing (SDB) in children is common. Interest in sleep tests, such as polygraphy (PG), which can be performed in a non-attended setting, are gaining is increasing. PG has, however, been little studied in children with co-morbidities other than obstructive sleep apnea (OSA), and in particular, if performed in a non-attended setting.

Medicago truncatula Phytoglobin 1.1 controls symbiotic nodulation and nitrogen fixation via the regulation of nitric oxide concentration.

In legumes, phytoglobins (Phytogbs) are known to regulate nitric oxide (NO) during early phase of the nitrogen-fixing symbiosis and to buffer oxygen in functioning nodules. However, their expression profile and respective role in NO control at each stage of the symbiosis remain little-known. We first surveyed the Phytogb genes occurring in Medicago truncatula genome.

The cultural heritage of pastoralism - local knowledge, state identity and the global perspective: the example of local breeds in Morocco.

Over the past few decades, the heritage designation process has come to impact on the way of life of many nomadic pastoralists across the world. Since the Convention Concerning the Protection of the World Cultural and Natural Heritage was adopted in 1972, policies for the conservation of protected areas have been implemented under the aegis of the United Nations Educational, Scientific and Cultural Organization (UNESCO), especially in countries of the South, with a varying impact on the practices and perceptions of pastoral communities. Heritage policies were further extended by the establishment of the list of Intangible Cultural Heritage (the Convention was adopted by the UNESCO General Conference in October 2003 and came into force in 2006) and the list of Cultural Landscapes (adoption in 1992, with the first site listed in 1993).