Publications by authors named "S Guarrera"
The adoption of soil and water conservation measures (SWCM) is essential for improving the use of natural resources and making the agro-systems more resilient to climate change. In this context, a three-years trial was carried-out in an orange orchard characterized by different soil management (SM, i.e.
View Article and Find Full Text PDFIntroduction: Ewing Sarcoma (EWS) has been reported in seven children with Down syndrome (DS). To date, a detailed assessment of this solid tumour in DS patients is yet to be made.
Methods: Here, we characterise a chemo-resistant mediastinal EWS in a 2-year-old DS child, the youngest ever reported case, by exploiting sequencing approaches.
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- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Article Synopsis
- Liquid biopsy utilizing cell-free DNA (cfDNA) analysis shows potential for non-invasive cancer diagnosis and monitoring, but the mechanisms behind cfDNA release from tumors are not fully understood.
- A study on colorectal cancer cell lines revealed that increased cfDNA levels were linked to slower cell growth and more cell death, with less DNA methylation correlating to higher cfDNA shedding.
- Researchers developed a methylation signature to differentiate between high and low cfDNA releasers, which was validated on additional colorectal cancer cell lines and patient-derived organoids, demonstrating its predictive capability for cfDNA release.
Unlabelled: The quantification of soil carbon dioxide (CO) flux represents an indicator of the agro-ecosystems sustainability. However, the monitoring of these fluxes is quite challenging due to their high spatially-temporally variability and dependence on environmental variables and soil management practices.In this study, soil CO fluxes were measured using a low-cost accumulation chamber, that was realized for the surveys, in an orange orchard managed under different soil management (SM, bare mulched soils) and water regime (WR, full irrigation regulated deficit irrigation) strategies.
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