Publications by authors named "S Grubb"
Microglia contact cerebral vasculature through gaps between astrocyte endfeet.
J Cereb Blood Flow Metab
December 2024
Article Synopsis
- Approximately 20% of microglia were found to form "plugs," or direct contact points with blood vessels, predominantly located near the cell body and favored near venules.
- This research highlights the significance of microglial contact with endothelial cells over pericytes, providing a basis for understanding how these interactions influence brain function and disease.
Whether top-down feedback modulates perception has deep implications for cognitive theories. Debate has been vigorous in the domain of spoken word recognition, where competing computational models and agreement on at least one diagnostic experimental paradigm suggest that the debate may eventually be resolvable. Norris and Cutler (2021) revisit arguments against lexical feedback in spoken word recognition models.
View Article and Find Full Text PDFNeurons communicate with vasculature to regulate blood flow in the brain, a process maintained by the neurovascular unit (NVU). This interaction, termed neurovascular coupling, is believed to involve astrocytes or molecules capable of traversing the astrocytic endfeet. The precise mechanism, however, remains elusive.
View Article and Find Full Text PDFOsteomyelitis of the skull is a particularly life-threatening condition. Infections are usually at the base of the skull and typically occur following dissemination from another site, such as the external auditory canal. Typical organisms include and species.
View Article and Find Full Text PDFArticle Synopsis
- - The Mouse Phenome Database is a curated repository that provides detailed information and tools for analyzing attributes of various mouse populations, including 657 mouse strains and community standard ontologies.
- - It has evolved from focusing on inbred strains to encompassing diverse populations like the Diversity Outbred and Collaborative Cross, and recently includes data from the International Mouse Phenotyping Consortium.
- - The database offers an interactive tool suite for users to perform analyses such as correlation and trait pattern matching, supporting research on phenotypic variation related to health and disease across different lifespans.