Publications by authors named "S Greenfield"
Age-related cognitive decline presents a healthcare challenge. While age-related mechanisms are mainly studied in humans, animal models provide key insights. Despite evidence of sex-specific differences in aging and cognition, the impact of age on female rodent behaviour is underexplored.
View Article and Find Full Text PDFDuring development, a 14mer peptide, T14, modulates cell growth via the α-7 nicotinic acetylcholine receptor (α7 nAChR). However, this process could become excitotoxic in the context of the adult brain, leading to pathologies such as Alzheimer's disease (AD). Recent work shows that T14 acts selectively via the mammalian target of rapamycin complex 1 (mTORC1).
View Article and Find Full Text PDFHepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated efflux of hepatic metabolites by Mrp3 and reuptake by Oatp transporters in sequential hepatocytes until eventual biliary efflux by Mrp2. Sorafenib-glucuronide (SFB-G), the major metabolite of sorafenib (SFB), undergoes hepatocyte hopping, leading to efficient biliary elimination.
View Article and Find Full Text PDFAim: The EarLy Surveillance for Autoimmune (ELSA) study aims to explore the feasibility and acceptability of UK paediatric general population screening for type 1 diabetes.
Methods: We aim to screen 20,000 children aged 3-13 years for islet-specific autoantibodies through dried blood spot sample collection at home, hospital or community settings. Children with two or more autoantibodies are offered metabolic staging via oral glucose challenge testing.
Article Synopsis
- The COVID-19 pandemic increased the reliance on telemedicine, particularly in maternity care, leading to the BUMP trials which evaluated self-monitoring blood pressure for pregnant individuals at risk of hypertension.
- Qualitative interviews with 39 pregnant women revealed that while self-monitoring was generally seen as reassuring and empowering, it also created uncertainty and added responsibility, causing some women to opt out of the intervention.
- Ultimately, the BUMP trials did not demonstrate significant improvements in early detection or management of hypertension from blood pressure self-monitoring in pregnant women at higher risk for preeclampsia.