Publications by authors named "S Graydon Tope"
Background: Candidemia is a serious complication in pediatric patients with congenital heart defects (CHD) after cardiac surgery. Information about the epidemiology, clinical characteristics and risk factors for candidemia in this vulnerable population remains limited.
Methods: This retrospective case-control study was conducted in 2 pediatric intensive care units between 2004 and 2019.
Article Synopsis
- The SARS-CoV-2 pandemic in Africa has varied significantly across countries, and its overall impact remains unclear.
- An analysis of 8,746 genomes from 33 African countries indicated that most outbreaks originated from Europe before international travel restrictions took effect.
- As the pandemic continued, increased movement and local transmission led to the emergence of several variants within Africa, emphasizing the need for a strong pandemic response on the continent to prevent becoming a source of new variants.
Once described as mere "bags of enzymes," bacterial cells are in fact highly organized, with many macromolecules exhibiting nonuniform localization patterns. Yet the physical and biochemical mechanisms that govern this spatial heterogeneity remain largely unknown. Here, we identify liquid-liquid phase separation (LLPS) as a mechanism for organizing clusters of RNA polymerase (RNAP) in Using fluorescence imaging, we show that RNAP quickly transitions from a dispersed to clustered localization pattern as cells enter log phase in nutrient-rich media.
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