Association between polymorphisms in , and genes and covid-19 severity in Southern Brazil.

Background: A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.

Objective: The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in ; rs2292151 in ; rs1758566 in ; rs1800629 in , and rs1800795 in with the severity of Covid-19.

Methods: A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil.

Superradiant Detection of Microscopic Optical Dipolar Interactions.

The interaction between light and cold atoms is a complex phenomenon potentially featuring many-body resonant dipole interactions. A major obstacle toward exploring these quantum resources of the system is macroscopic light propagation effects, which not only limit the available time for the microscopic correlations to locally build up, but also create a directional, superradiant emission background whose variations can overwhelm the microscopic effects. In this Letter, we demonstrate a method to perform "background-free" detection of the microscopic optical dynamics in a laser-cooled atomic ensemble.

Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD.

We report a case of mediastinal cryptococcosis with thyroid invasion in a patient who presented dry cough and persistent dyspnea. This patient has been treated for COPD, presenting no clinical responses. Spirometry showed fixed flattening of inspiratory and expiratory loops, suggesting extrinsic tracheal compression.

Clustering of nuclei in multinucleated hyphae is prevented by dynein-driven bidirectional nuclear movements and microtubule growth control in Ashbya gossypii.

During filamentous fungus development, multinucleated hyphae employ a system for long-range nuclear migration to maintain an equal nuclear density. A decade ago the microtubule motor dynein was shown to play a central role in this process. Previous studies with Ashbya gossypii revealed extensive bidirectional movements and bypassings of nuclei, an autonomous cytoplasmic microtubule (cMT) cytoskeleton emanating from each nucleus, and pulling of nuclei by sliding of cMTs along the cortex.