Publications by authors named "S Granon"

We present adult normalized data for MindPulse (MP), a new tool evaluating attentional and executive functioning (AEF) in decision-making. We recruited 722 neurotypical participants (18-80 years), with 149 retested. The MP test includes three tasks: Simple Reaction Time (SRT), Go/No-go, and complex Go/No-go, involving perceptual components, motor responses, and measurements of reaction time (RT) and correctness.

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Article Synopsis
  • Oxytocin (OT) is a hormone that plays a key role in how mammals behave socially, and it is stored in special structures in the brain called LDCVs.
  • Researchers found that tiny channels in lysosomes (called TPCs) are important for releasing oxytocin by helping prepare these storage units, even if they don't directly release it right away.
  • Mice that couldn’t use TPCs showed less oxytocin and struggled with social behaviors, but giving them oxytocin helped them act normally again.
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The cholinergic system is an important modulator of brain processes. It contributes to the regulation of several cognitive functions and emotional states, hence altering behaviors. Previous works showed that cholinergic (nicotinic) receptors of the prefrontal cortex are needed for adapted social behaviors.

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In our contemporary societies, environmental issues are more and more important. An increasing number of studies explore the biological processes involved in environment perception and in particular try to highlight the mechanisms underlying the perception of environmental scenes by our brain. The main objective of the present study was to establish whether the visualization of clean and polluted environmental scenes would lead to differential postural reactions.

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In this paper, we review recent (published and novel) data showing inter-individual variation in decision-making strategies established by mice in a gambling task (MGT for Mouse Gambling Task). It may look intriguing, at first, that congenic animals develop divergent behaviors. However, using large groups of mice, we show that individualities emerge in the MGT, with about 30% of healthy mice displaying risk-averse choices while about 20-25% of mice make risk-prone choices.

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