Publications by authors named "S Granegger"
Background: Left ventricular ejection fraction (LVEF) is a valuable measure to assess left ventricular systolic function. Lipid lowering therapy by statins has been shown to have an impact on LVEF already after a 6 months treatment. Higher doses of statins have been claimed to be more effective as compared to a conventional one and even a difference between lipophilic and hydrophilic compounds has been reported.
View Article and Find Full Text PDFObjective: Platelet labeling is used to study platelets in vivo in terms of diagnosing intravascular thrombosis, as well as studying their role and biological activity in atherosclerosis. A low labeling efficiency (LE) can negatively impair testing results. Labeling efficiency depends on various factors, including low-density-lipoprotein (LDL)-cholesterol levels in the blood.
View Article and Find Full Text PDFArticle Synopsis
- There is a need for non-invasive methods to detect atherosclerotic lesions, and Indium-111-HIG has shown some ability to accumulate in certain vascular lesions.
- Earlier studies revealed that In-111-HIG scintigraphy had high sensitivity (70%-77%) but low specificity (33%-41%), leading to a conclusion that it was not promising for human studies.
- However, a 5-year follow-up indicated that patients with positive In-111-HIG results had significantly higher rates of vascular problems and death, suggesting it may identify a high-risk population rather than specific lesions at risk.
Imaging of tumors with cationic tracers, especially with technetium-99 methoxy isobutyl isonitrile ((99m)Tc-MIBI), revealed high specificity for the diagnosis and follow up of various malignancies. However, these radiopharmaceuticals are of limited value for the diagnosis of malignancies of the abdominal region due to the immediate biliary secretion of the tracer and the associated high background activity. In a prospective, single-blinded protocol, patients with endoscopically diagnosed gastrointestinal malignancies were assigned to undergo (99m)Tc-MIBI imaging of the abdomen.
View Article and Find Full Text PDFPlatelet function after single [153Sm]EDTMP therapy in prostate cancer.
Q J Nucl Med Mol Imaging
December 2006
Aim: Aim of the study was to assess whether [153Sm] EDTMP therapy at a low-dose is associated with platelet activation.
Methods: In 29 patients suffering from metastatic prostate cancer platelet count and various platelet function parameters have been monitored for 2 months after a single (the first) application of 1.1 GBq mCi [153Sm]EDTMP.