Publications by authors named "S Grandjean Lapierre"
Background: Mycobacterial culture is routinely performed to diagnose tuberculosis (TB) in Canada. Globally, meta-analyses suggest that up to 2% of positive cultures are falsely positive for due to laboratory cross-contamination. Five patients from distinct clinical institutions in Montréal were diagnosed with culture-positive TB as their clinical samples were processed in a centralized mycobacteria laboratory.
View Article and Find Full Text PDFWhole genome sequencing of M. tuberculosis for disease control in high-burden settings: study protocol for a cluster randomized controlled trial evaluating different community-wide intervention strategies in rural Madagascar.
Trials
October 2024
Article Synopsis
- The study explores the potential benefits of using whole genome sequencing of Mycobacterium tuberculosis to improve tuberculosis case detection in high-incidence areas, as previous research has shown its effectiveness in identifying outbreaks and transmission events.* -
- A cluster randomized controlled trial will take place in 48 rural village groups in Madagascar, comparing three intervention methods: standard care with microscopy, active case finding with PCR testing, and a novel approach that includes both PCR testing and genome sequencing.* -
- The primary goal is to assess the number of tuberculosis cases detected per 100,000 people after one year of different interventions, aiming to enhance understanding of how genomic tracking can improve tuberculosis management in regions with high disease levels.*
Background: Computer-aided detection (CAD) algorithms for automated chest X-ray (CXR) reading have been endorsed by the World Health Organization for tuberculosis (TB) triage, but independent, multi-country assessment and comparison of current products are needed to guide implementation.
Methods: We conducted a head-to-head evaluation of five CAD algorithms for TB triage across seven countries. We included CXRs from adults who presented to outpatient facilities with at least two weeks of cough in India, Madagascar, the Philippines, South Africa, Tanzania, Uganda, and Vietnam.
Cough is a common and commonly ignored symptom of lung disease. Cough is often perceived as difficult to quantify, frequently self-limiting, and non-specific. However, cough has a central role in the clinical detection of many lung diseases including tuberculosis (TB), which remains the leading infectious disease killer worldwide.
View Article and Find Full Text PDFEnd-of-life (EoL) planning and the drafting of advance care directives (ACD) are challenging for older adults. As part of a mixed study, the content of 18 semi-structured interviews with Swiss community-dwelling older adults was analyzed to investigate contextual and interactional aspects that might influence their choice to complete ACD. Results show that EoL planning vary greatly.
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