Publications by authors named "S Graceline Jasmine"
Introduction: This paper presents a multichannel deep-learning method for detecting lung diseases using chest X-ray images. Using EfficientNetB0 through EfficientNetB7 pretrained models, the methodology offers improved performance in classifying COVID-19, viral pneumonia, and normal chest Xrays.
Methods: The EfficientNetB2 model was customized by incorporating Squeeze-and-Excitation (SE) blocks and the Convolutional Block Attention Module (CBAM) to improve the model's attention mechanisms.
Article Synopsis
- Literature on pregnancy outcomes for individuals with a solitary kidney is limited and mainly derived from renal donors.
- Unilateral renal agenesis, a condition affecting 1 in 1500 people, can lead to complications like resistant hypertension during pregnancy.
- The case presented discusses the use of Eplerenone, an aldosterone blocker, to manage resistant hypertension in a pregnant patient with secondary hyperaldosteronism linked to renal agenesis.*
Histiocytoid Sweet syndrome (H-SS) is a histopathological variant of Sweet syndrome (SS) defined by cutaneous infiltration of immature myeloid cells morphologically resembling histiocytes. The association of H-SS with underlying malignancy, particularly myelodysplastic syndromes, is well-established. Myelodysplasia cutis (MDS-cutis) has been proposed to describe cases historically diagnosed as H-SS but characterized by shared clonality of the myeloid infiltrate in skin and bone marrow.
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- Lysine-specific demethylase 1 (LSD1) plays a key role in the progression of metastatic castration-resistant prostate cancer (mCRPC), particularly in its neuroendocrine form (NEPC), highlighting the need for effective LSD1 inhibitors like bomedemstat for treating these cancers.
- Bomedemstat was evaluated using various scientific methods, showing it is an irreversible inhibitor of LSD1 with significantly higher specificity over monoamine oxidase enzymes, and it effectively reduces tumor growth in prostate cancer models.
- The study found that bomedemstat accumulates well in tumors after oral administration and has an overall tolerable safety profile with manageable side effects, supporting its clinical