Publications by authors named "S Gourinath"
Helicobacter pylori deoxyuridine triphosphate nucleotidohydrolase (HpdUTPase) is a key enzyme in the synthesis of the thymidine nucleotide pathway. It catalyzes the hydrolysis of dUTP to dUMP and releases pyrophosphate. This enzyme has been shown to be essential in several pathogenic organisms.
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- Phototropin (Phot) is a protein that helps plants sense blue light and has been around for a long time in plant evolution.
- Scientists studied a type of green algae called Klebsormidium nitens to learn how it adapted from water to land.
- They discovered different versions of the KnLOV1 protein and found out how fast they recover after absorbing light, which helps explain how plants react to light over time.
Objective: Proteasomes are conserved proteases crucial for proteostasis in eukaryotes and are promising drug targets for protozoan parasites. Yet, the proteasomes of Entamoeba histolytica remain understudied. The study's objective was to analyse the differences in the substrate binding pockets of amoeba proteasomes from those of host, and computational modelling of β5 catalytic subunit, with the goal of finding selective inhibitors.
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- Vibrio cholerae, the bacteria causing cholera, uses a type VI secretion system (T6SS) to enhance its virulence in both aquatic environments and human hosts.
- Valine glycine repeat protein G1 (VgrG1) and hemolysin coregulated protein (HCP) are key molecules in T6SS, with HCP shown to interact with host cell actin and potentially influence cytoskeletal changes during infection.
- Research indicates that HCP has an actin-binding site, and when overexpressed, it aligns with actin stress fibers, indicating its role in altering host cell structure, which is essential for understanding how the bacteria causes disease and developing treatments.
Amoebiasis, a widespread disease caused by the protozoan parasite , poses challenges due to the adverse effects of existing antiamoebic drugs and rising drug resistance. Novel targeted drugs are in need of the hour to combat the prevalence of this disease. Given the significance of cysteine for survival, the rate-determining step in the serine (the sole substrate of cysteine synthesis) biosynthetic pathway, i.
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