Comparing scissors and scalpels to a novel surgical instrument: a biomechanical sectioning study.

Background: This study introduces a novel surgical instrument to reduce iatrogenic nerve injuries during procedures such as carpal tunnel and ulnar nerve decompression surgery. These injuries often result from direct damage to surrounding tissues by surgical instruments, whose designs have remained largely unchanged over the past decades. The novel device is a modified surgical forceps that has a deployable surgical scalpel that runs along a groove on the forceps.

Single-cell resolution of intestinal regeneration in pythons without crypts illuminates conserved vertebrate regenerative mechanisms.

Canonical models of intestinal regeneration emphasize the critical role of the crypt stem cell niche to generate enterocytes that migrate to villus ends. Burmese pythons possess extreme intestinal regenerative capacity yet lack crypts, thus providing opportunities to identify noncanonical but potentially conserved mechanisms that expand our understanding of regenerative capacity in vertebrates, including humans. Here, we leverage single-nucleus RNA sequencing of fasted and postprandial python small intestine to identify the signaling pathways and cell-cell interactions underlying the python's regenerative response.

Common DNA sequence variation influences epigenetic aging in African populations.

Aging is associated with genome-wide changes in DNA methylation in humans, facilitating the development of epigenetic age prediction models. However, most of these models have been trained primarily on European-ancestry individuals, and none account for the impact of methylation quantitative trait loci (meQTL). To address these gaps, we analyzed the relationships between age, genotype, and CpG methylation in 3 understudied populations: central African Baka (n = 35), southern African ‡Khomani San (n = 52), and southern African Himba (n = 51).

Epidemic modeling for misinformation spread in digital networks through a social intelligence approach.

Online digital networks, including social networks, have significantly impacted individuals' personal and professional lives. Aside from exchanging news and topics of interest, digital networks play an essential role in the diffusion of information, which frequently significantly impacts worldwide societies. In this paper, we present a new mathematical epidemic model for digital networks that considers the sentiment of solitary misinformation in the networks and characteristics of human intelligence that play an important role in judging and spreading misinformation inside the networks.