Publications by authors named "S GooSSen"

We treated a 34-year-old male patient with a diagnosis of both schizophrenia and Brugada syndrome (BrS). In the literature we found clues for ion channel defects as a possible common pathophysiological mechanism in these disorders. Awareness of the link with BrS can improve cardiac assessment and cardiac mortality in patients with schizophrenia, whereas the ion channel defects provide an interesting area for future research into pharmacotherapeutic possibilities.

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We present a systematic investigation of well-characterized, experimentally pure polystyrene (PS) rings with molar mass of 161 000 g/mol in dilute solutions. We measure the ring form factor at - and good-solvent conditions as well as in a polymeric solvent (linear PS of roughly comparable molar mass) by means of small-angle neutron scattering (SANS). Additional dynamic light scattering (DLS) measurements support the SANS data and help elucidate the role of solvent quality and solution preparation.

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Using neutron spin echo spectroscopy, we show that the segmental dynamics of polymer rings immersed in linear chains is completely controlled by the host. This transforms rings into ideal probes for studying the entanglement dynamics of the embedding matrix. As a consequence of the unique ring topology, in long chain matrices the entanglement spacing is directly revealed, unaffected by local reptation of the host molecules beyond this distance.

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Considering topology among all polymer architectures polymer rings are unique, as they are the simplest closed structures without ends. In this review we present recent experimental advances addressing the structure and dynamics of rings. We focus mainly on neutron scattering results that reveal experimental insight on a molecular scale.

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We present neutron scattering data on the structure and dynamics of melts from polyethylene oxide rings with molecular weights up to ten times the entanglement mass of the linear counterpart. The data reveal a very compact conformation displaying a structure approaching a mass fractal, as hypothesized by recent simulation work. The dynamics is characterized by a fast Rouse relaxation of subunits (loops) and a slower dynamics displaying a lattice animal-like loop displacement.

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