Publications by authors named "S Gonzalez-Reyes"
Between March 2020 and February 2021, the state of Baja California, Mexico, which borders the United States, registered 46,118 confirmed cases of COVID-19 with a mortality rate of 238.2 deaths per 100,000 residents. Given limited access to testing, the population prevalence of SARS-CoV-2 infection is unknown.
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- MIS-C is a serious inflammatory condition that can occur in children 2 to 4 weeks after infection with SARS-CoV-2, characterized by inflammation and heart issues.
- Despite being recognized for over two years, effective treatments for MIS-C are still being studied.
- The review explores the potential of natural compounds that have antioxidant and anti-inflammatory properties as possible treatments to mitigate hyperinflammation associated with MIS-C.
Background: Ischemic kidney injury is a common clinical condition resulting from transient interruption of the kidney's normal blood flow, leading to oxidative stress, inflammation, and kidney dysfunction. The ketogenic diet (KD), a low-carbohydrate, high-fat diet that stimulates endogenous ketone body production, has potent antioxidant and anti-inflammatory effects in distinct tissues and might thus protect the kidney against ischemia and reperfusion (IR) injury.
Main Methods: Male Wistar rats were fed a KD or a control diet (CD) for three days before analyzing metabolic parameters or testing nephroprotection.
Article Synopsis
- Research investigated the cytotoxic effects of hexane, chloroform, and methanol extracts from roots on various cancer cell lines, with hexane extract showing the highest activity (IC of 10.6 µg mL).
- Three diterpenoids were isolated from the hexane extract and tested for their effects on cancer cells: one showed moderate activity while another was practically inactive.
- The active compound was found to induce arrest in the G0/G1 phase of the cell cycle, likely through DNA damage, and also reduced cell migration in specific cancer cells.
Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a combination of several mechanisms. We recently demonstrated that fasting protects the rat kidney against oxidative stress and mitochondrial dysfunction in early acute kidney injury, and also against fibrosis development. Here we show that preoperative fasting preserves redox status and mitochondrial homeostasis at the chronic phase of damage after severe ischemia.
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