Publications by authors named "S Gomez-Fuentes"
The ability to modulate the host immune response has allowed some parasites to establish themselves in the tissues of an immunocompetent organism. While some parasite excretion/secretion products (ESPs) were recently reported to induce differentiation of regulatory T cells (Tregs), their identity is not known. This work is aimed to identify and characterize ESPs of Taenia crassiceps cysticerci linked with Treg induction in vivo.
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- Murine cysticercosis serves as a model for studying human neurocysticercosis, with genetic and immune differences influencing susceptibility in mouse strains.
- The study focuses on T regulatory cells (Tregs) and their role in parasite establishment, comparing responses in susceptible BALB/cAnN and non-susceptible C57BL/6 mice.
- Findings suggest that higher Treg levels in BALB/cAnN mice aid in parasite survival, while non-susceptible strains may rely on Tregs for immune balance rather than infection support.
Article Synopsis
- The flatworm Taenia solium causes cysticercosis in humans and pigs, leading to a serious condition called neurocysticercosis, particularly in rural areas of Mexico and other developing countries.
- This study focuses on identifying and characterizing proteins secreted by T. solium cysticerci from infected pigs using advanced proteomic techniques.
- The research identified 108 conserved and 186 differential proteins, including 14 potentially vaccine-targeting proteins, and revealed a link between the parasite's signaling pathways and human cancer, along with the novel mechanism of protein release via exosome-like structures.
Neglected tropical diseases (NTDs) share certain traits: they are parasitic infections, prevailing in tropical environments and affecting marginalized sectors of the population. Six NTDs - ascariasis, cysticercosis, echinococcosis, hookworm infection, onchocerciasis and trichuriasis - all of them endemic in Latin America and the Caribbean (LAC), are analysed in this work. This review aims to discuss key information on the function of excretory/secretory (E/S) proteins from these parasites in their infectivity, pathogeny and diagnosis.
View Article and Find Full Text PDFObjective: The aim of this study is to analyze the immune-endocrine profile in neurocysticercosis (NC) patients resistant to cysticidal treatment.
Methods: The inflammatory and regulatory responses of 8 resistant NC patients with extraparenchymal parasites and 5 healthy controls were evaluated through flow cytometry. Serum interleukin levels were measured by ELISA and catecholamines levels by high performance liquid chromatography.