Publications by authors named "S Gogia"
Despite a decline in global incidence, gastric cancer (GC) remains a major health concern. The development of GC is a sequential, multistage maladaptive process involving numerous different factors. Understanding the complexity of GC development is crucial for early detection, effective treatment, and, ultimately, prevention.
View Article and Find Full Text PDFBackground: The advent of immune checkpoint inhibitors (ICI) has brought about a significant transformation in the treatment of immunogenic tumors. On November 23, 2015, the United States Food and Drug Administration approved Nivolumab to treat metastatic renal cell carcinoma (RCC). We aimed to assess potential changes in the survival rates of patients with metastatic RCC at a population level after the approval of Nivolumab.
View Article and Find Full Text PDFIntroduction: One Health (OH) refers to the integration of human, animal, and ecosystem health within one framework in the context of zoonoses, antimicrobial resistance and stewardship, and food security. Telehealth refers to distance delivery of healthcare. A systems approach is central to both One Health and telehealth, and telehealth can be a core component of One Health.
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- The study investigates the safety and efficacy of efruxifermin, a drug that targets the FGF21 pathway, in patients with non-alcoholic steatohepatitis (NASH) and varying degrees of liver fibrosis during a 96-week phase 2b clinical trial.
- Conducted across 41 clinics in the USA, 128 eligible adult participants with confirmed NASH were randomly assigned to receive either efruxifermin (28 mg or 50 mg) or a placebo, with strict masking of group assignments.
- Primary outcomes focused on the proportion of patients experiencing at least a one-stage improvement in liver fibrosis without worsening NASH symptoms, with a total of 747