Publications by authors named "S Goeschl"
Background: Since the beginning of Alzheimer's disease research, the hypothesis that infections are to some extent associated with neurodegenerative processes has been tested repeatedly. Epidemiological studies on the associations between infections and dementia have reported conflicting results.
Objectives: This study analyses common hospital-treated infections (herpes, influenza, intestinal infections, pneumonia, sepsis, urinary tract infections) and their association with subsequent dementia and time until dementia onset.
Article Synopsis
- Early-onset dementia (EOD) has a genetic basis, with whole-exome sequencing (WES) being utilized for screening and gene discovery among affected individuals.
- In a study of 60 Austrian EOD patients, 20% were found to have likely disease-causing genetic variants, including notable genes like PSEN1 and APP, suggesting a need for further genetic understanding and patient counseling.
- The research highlights the importance of sharing genetic data and findings to enable collaboration and potentially identify new genetic risk factors in EOD across different patient groups.
Background And Purpose: Dementia prevalence is increasing, with numbers projected to double by 2050. Risk factors for its development include age and cardiovascular comorbidities, which are found more often in patients with dementia and should be treated properly to improve outcomes. In this case-control study, we analysed a large population-based prescription database to explore the patterns of co-medication in patients with dementia.
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