Radial club hand and Holt-Oram syndrome.

The authors describe the case of a young African girl born with a radial club hand associated with a pedicled floating thumb, no other orthopaedic malformation was detected. A ventricular septal defect necessitated surgery in emergency. In front of such malformative association, the Holt-Oram syndrome has been evoked.

[Cutis marmorata telangiectatica congenita. Apropos of 4 new cases].

Cutis Marmorata Phlebectasica is a rare congenital disorder characterized by persistent erythrocyanotic mottled areas associated with superficial phlebectases with cutaneous atrophy and ulcerations. The anomaly is present at birth. Spontaneous improvement is the rule.

[Hemisynthesis of antineoplastic conjugates with nitrogen-mustard proteins].

The synthesis of new conjugates with inhibitory action on tumour growth is investigated by linking amino functions of proteins compounds (lysozyme and alpha s-casein) through an amide linkage at the carboxylic function of nitrogen mustards (chlorambucil and melphalan). The polychlorambucil amides of lysozyme and alpha s-casein derivatives prepared showed experimental antitumour activity when these conjugates were screened against the experimental P388 leukemia. In the case of the conjugates lysozyme-melphalan, an antitumour activity is observed when the amino function of the drug is combined with the carboxylic functions of the protein contrary to the situation of the free amino function of the drug described into the literature.

Long-term follow up of a case of severe congenital chloride diarrhoea.

A patient with congenital chloride diarrhoea (CCD) is reported. The diagnosis on the 5th day of life was based on the watery stools with characteristic ionic composition. The neonate presented with abdominal distension necessitating laparotomy on day 1, followed by transverse colostomy on day 3, owing to persistent abdominal swelling.

[Isotope lymphography and its therapeutic implications].

Radiological lymphography presents drawbacks among which the risk of aggravation of the edema is most prominent. The authors report their experience with isotopic lymphography which best reproduces the physiological conditions of lymphatic drainage; it provides informations on the dermal or canalicular drainage route, the possible peripheral stasis or lymph leakage.