Publications by authors named "S Glasmacher"
Article Synopsis
- Multiple sclerosis (MS) is a chronic disease marked by the loss of myelin, leading to neurological problems, and the endocannabinoid system (ECS) is being explored as a potential treatment target.
- A study involving 74 MS patients and 80 controls analyzed lipid levels in cerebrospinal fluid (CSF) and serum, revealing that most lipidomic changes in MS do not match between these two fluids.
- Findings showed that specific lipids, including endocannabinoids, varied by sex and age, emphasizing the need to study eCBs in CSF instead of blood to better understand MS-related changes.
Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of the endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid intimately linked to central nervous system (CNS) disorders associated with neuroinflammation. In the quest for novel MAGL inhibitors, a focused screening approach on a Roche library subset provided a reversible benzoxazinone hit exhibiting high ligand efficiency. The subsequent design of the three-dimensional -hexahydro-pyrido-oxazinone (-HHPO) moiety as benzoxazinone replacement enabled the combination of high MAGL potency with favorable ADME properties.
View Article and Find Full Text PDFIntroduction: Pain and cognitive dysfunction are separately known to be important manifestations of multiple sclerosis (MS). Although pain is a complex subjective phenomenon with affective and cognitive aspects, it is not known if people with MS reporting pain are at greater risk of reduced performance in objective tests of cognition. The presence or direction of any association remains to be clarified, as do the roles of confounders such as fatigue, medication and mood.
View Article and Find Full Text PDFBackground: The aim of this study was to evaluate the applicability and advantages of intraoperative imaging using a 3D flat panel in the treatment of C1/2 instabilities.
Materials: Prospective single-centered study including surgeries at the upper cervical spine between 06/2016 and 12/2018. Intraoperatively thin K-wires were placed under 2D fluoroscopic control.