Publications by authors named "S Girault"
Surgery in rare bleeding disorders: the prospective MARACHI study.
Res Pract Thromb Haemost
October 2023
Article Synopsis
- Bleeding risk assessment before surgery in patients with rare inherited bleeding disorders is complex, despite established bleeding scores and clotting factor measurements.
- A study involving 178 patients with low coagulation levels analyzed how hemostasis experts managed bleeding risks during 207 surgical procedures and the resulting bleeding outcomes.
- Results showed that most surgeries were performed without factor replacement, particularly in mild deficiencies, and indicated that factor levels and the type of surgery are more critical for deciding perioperative treatment than bleeding scores.
Background: Retrospective studies in hematological unit have suggested that single red blood cell (1-RBC) unit transfusion policy may reduce the number of RBC used without negative clinical impact.
Method: Acute leukemia patients requiring intensive chemotherapy or patients receiving autologous or allogeneic transplantation were randomly assigned to receive either single RBC (1-RBC arm) or double RBC (2-RBC arm) per transfusion with a hemoglobin trigger of 8 g/dL. The primary composite endpoint was the percentage of patients experiencing serious complications, such as a non-hematological adverse event grade ≥ 3 or intensive care admission or death.
Article Synopsis
- The study explores the genetic predisposition to myeloid malignancies, highlighting a growing area of intersection between hematology and genetics, which has led the WHO to categorize certain tumors as "Myeloid Neoplasms with Germline Predisposition."
- Researchers compared next-generation sequencing (NGS) data across multiple sample types from 29 patients and their 44 relatives, assessing the effectiveness of saliva as a diagnostic tool.
- The findings revealed that while saliva could be useful for relatives, it was only effective for a minority of patients, prompting recommendations to collect saliva during remission and suggesting hair follicles as an alternative biopsy method.
Article Synopsis
- A study was conducted with 180 pregnant women and 168 nonpregnant women with immune thrombocytopenia (ITP) to assess the risks of ITP worsening during pregnancy and neonatal ITP (NITP).
- The findings showed that while pregnant women with ITP had a higher likelihood of severe thrombocytopenia recurrence and treatment changes, the overall risk of severe bleeding did not differ from nonpregnant women.
- NITP was identified in 14% of neonates, particularly linked to a mother's past history of NITP and low platelet counts close to delivery, providing valuable insights for advising women with ITP.