Publications by authors named "S Giovani"
Article Synopsis
- Disopyramide has been commonly used to treat left ventricular outflow obstruction (LVOTO) in patients with obstructive hypertrophic cardiomyopathy (oHCM), but its real-world efficacy and the patient characteristics that predict a positive response are still not well understood.
- A study involving 1,527 HCM patients found that about 23% had LVOTO, and among those, 32% responded positively to disopyramide therapy, with most responders being in a less severe NYHA functional class (I/II).
- The treatment showed a generally safe profile, with no major life-threatening arrhythmias reported, but side effects were experienced by 26% of patients, mainly related to anticholinergic
Article Synopsis
- - The study analyzed the causes of death in 161 hypertrophic cardiomyopathy (HCM) patients over a 20-year period, finding that 64% died from HCM-related issues, primarily heart failure, while 36% died from other causes.
- - Younger patients were more likely to experience sudden cardiac death (SCD), while those who died from heart failure often fell into older age groups, suggesting less availability of transplant options.
- - The modes of death varied by HCM disease stage, with SCD being more common in the early "classic" stage and heart failure deaths increasing significantly in later stages, highlighting a shift in mortality risk as the disease progresses.
Micheliolide (MCL) is a naturally occurring sesquiterpene lactone that selectively targets leukemic stem cells (LSCs), which persist after conventional chemotherapy for myeloid leukemias, leading to disease relapse. To overcome modest MCL cytotoxicity, analogs with ≈two-threefold greater cytotoxicity against LSCs are synthesized via late-stage chemoenzymatic C-H functionalization. To enhance bone marrow delivery, MCL analogs are entrapped within bone-targeted polymeric nanoparticles (NPs).
View Article and Find Full Text PDFBackground: SARS-CoV-2 infection might be associated with cardiac complications in low-risk populations, such as in competitive athletes. However, data obtained in adults cannot be directly transferred to preadolescents and adolescents who are less susceptible to adverse clinical outcomes and are often asymptomatic.
Objectives: We conducted this prospective multicentre study to describe the incidence of cardiovascular complications following SARS-CoV-2 infection in a large cohort of junior athletes and to examine the effectiveness of a screening protocol for a safe return to play.
The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of action have been hindered by the paucity of preexisting functional groups amenable for late-stage derivatization of this molecule. Here, we report the implementation of a probe-based P450 fingerprinting strategy to rapidly evolve engineered P450 catalysts useful for the regio- and stereoselective hydroxylation of micheliolide at two previously inaccessible aliphatic positions in this complex natural product.
View Article and Find Full Text PDF