Publications by authors named "S Giovagnoli"
Background/objectives: The aim of this study is to shed light on activity-based prospective memory upon the awakening and its association with motor sleep inertia in different phenotypes of insomnia disorder.
Methods: To this end, 67 patients with insomnia and 51 healthy controls took part in the study. After enrollment, previously proposed actigraphic quantitative criteria were adopted, and the following phenotypes of insomnia disorder were observed in the patient sample: sleep onset ( = 12), maintenance ( = 19), mixed ( = 17), and negative misperception ( = 19).
The aim of the present work was to analyze possible differences in the wake-sleep and sleep-wake transition in relation to adolescents' circadian preference using actigraphy. Overall, 729 participants were enrolled in the research and 443 of them wore actigraphs on the non-dominant wrist for at least three nights. According to the reduced Morningness-Eveningness Questionnaire for Children and Adolescents cut-off scores, 61 participants belonged to the evening-type category, while 38 participants belonged to the morning-type.
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- The aryl hydrocarbon receptor (AhR) is significant in immune and metabolic processes, but its complexity and diverse ligands make drug discovery challenging.
- Researchers created quantitative structure-activity relationship (QSAR) models by analyzing 978 molecules to improve predictions of AhR activity.
- The best classification model achieved 76% accuracy and led to the development of a user-friendly web application, potentially paving the way for further studies on how ligand structure affects AhR modulation.
Article Synopsis
- * Recent research indicates that the gut microbiome plays a crucial role in cardiovascular health by activating immune and inflammatory responses, impacting various CVDs.
- * This review focuses on how metabolites from gut microbiota, particularly those derived from tryptophan, interact with immune systems, potentially leading to new, microbiome-based strategies for CVD treatment.
is an environmental fungus recently included in the fungal high-priority pathogens by the World Health Organization. While immunodeficiency and/or pre-existing lung damage represent a well-recognized fertile ground for fungal growth, it is increasingly being recognized that severe viral infections may similarly favor colonization and infection, as recently experienced in the Coronavirus disease 2019 (COVID-19) pandemic. Herein, in a murine model of COVID-19-associated pulmonary aspergillosis (CAPA), obtained by the concomitant exposure to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike protein and conidia, we found that the microbial compound indole-3-aldehyde (3-IAld) was able to ameliorate CAPA by working at multiple levels during viral infection and fungal superinfection, including epithelial barrier protection, promotion of antiviral responses, and limiting viral replication.
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