Publications by authors named "S Gingele"
Article Synopsis
- Diagnosing multiple sclerosis (MS) is complicated by varied symptoms and lack of specific biomarkers, compounded by the presence of concurrent autoimmune diseases (AID) and non-specific antibodies, which can hinder effective management.* -
- A study conducted on 315 patients from 2010 to 2017 revealed that 13.7% had concurrent AID, with autoimmune thyroiditis being the most common, but these conditions did not significantly affect MS progression or relapse rates over a median follow-up of 9 months.* -
- The findings suggest that while AIDs are prevalent at the onset of MS, they do not influence neurofilament light (NfL) levels, indicative of similar disease activity, pointing to a need
Background: Sjögren's syndrome is an autoimmune disease characterized by sicca symptoms and various extraglandular manifestations including vasculitis. Neurological involvement occurs frequently (Neuro-Sjögren) and often mimics immune neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP).
Objectives: We aim to assess relevant differences in vessel density (VD) in Optical Coherence Tomography Angiography (OCTA) in those diseases to use it as an easily available diagnostic tool.
Rapid depletion of CD20 B and T cells following ofatumumab therapy onset.
Mult Scler Relat Disord
November 2024
Background: The humanized monoclonal anti-CD20-antibody ofatumumab is highly effective in treating relapsing multiple sclerosis (MS).
Objective: This study aimed to investigate the immanent effect of ofatumumab on the peripheral immune system, particularly targeting B and T cells expressing CD20.
Methods: Blood samples of 53 MS patients receiving ofatumumab were collected prior to first application and after one week, two weeks and three months.
Article Synopsis
- Guillain-Barré syndrome and neuralgic amyotrophy are linked to HEV genotype 3, while myasthenia gravis is connected to genotype 4, but the link between CIDP and HEV remains unclear.
- A study tested 102 CIDP patients and found that 64% had positive anti-HEV IgG results, but no patients showed signs of active HEV infection (viremia).
- Higher anti-HEV positivity rates in CIDP patients suggest that HEV exposure might contribute to the development of CIDP, especially in areas where HEV genotype 3 is common, independent of IVIG treatment effects.
Background: Data on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients with MOGAD.
Methods: The CogniMOG-Study is a prospective, longitudinal and multicentre observational study of 113 patients with MOGAD.