Publications by authors named "S Gierl"

Article Synopsis
  • The peripheral immune system influences neurodegenerative diseases like Alzheimer's by both protecting the brain and causing inflammation; however, the exact mechanisms are not fully understood.
  • Researchers found large Aβ aggregates in the plasma of patients with mild cognitive impairment, which are linked to early signs of Alzheimer's pathology and a decrease in certain monocytes.
  • The study identifies complement receptor 4 as a key player in interacting with amyloids, enhancing phagocytosis and lysosomal activity in microglia, and suggests that Aβ aggregates may help recruit immune cells into the brain, affecting the disease process.
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Experiments have been carried out using the deposition-based Direct Thoron Progeny Sensors (DTPS) in a thoron experimental house. The objective was to study the thoron decay product characteristics such as the deposition velocities, spatial variability and dependence on aerosol particle concentrations. Since the deposition velocity is an important characteristic in the calibration of the DTPS, it is very important to study its dependence on aerosol concentration in a controlled environment.

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The radioactive noble gas radon (Rn) and its decay products have been considered a health risk in the indoor environment for many years because of their contribution to the radiation dose of the lungs. The radioisotope thoron (Rn) and its decay products came into focus of being a health risk only recently. The reason for this is its short half-life, so only building material can become a significant source for indoor thoron.

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In recent years, elevated thoron concentrations were found in houses built of unfired clay. In this study experiments were carried out in 17 traditional and modern clay houses in Germany to obtain an overview of indoor thoron in such houses. Long-term measurements over an 8-week period were performed using a newly developed Unattended Battery-Operated Progeny Measurement Device (UBPM) for measuring thoron progeny.

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An integrating measurement device for the concentration of airborne thoron decay products was designed and calibrated. It is suitable for unattended use over up to several months also in inhabited dwellings. The device consists of a hemispheric capacitor with a wire mesh as the outer electrode on ground potential and the sampling substrates as the inner electrode on +7.

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