Publications by authors named "S Giddaluru"
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes.
View Article and Find Full Text PDFMajor mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) have recently provided evidence for shared genetic factors as well. Genetic overlaps are usually identified at the single-marker level.
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- Scientists studied the brain's outer layer, called the cerebral cortex, to learn how genes can affect its structure.
- They looked at brain scans from over 51,000 people and found 199 important genetic markers that relate to how the cortex is shaped.
- The study showed that these genetic markers are linked to different brain functions and conditions like thinking skills, sleep problems, and ADHD.
Article Synopsis
- Subcortical brain structures play key roles in motion, emotions, learning, and consciousness, and their volumes are influenced by genetic variations.
- A study analyzed nearly 40,000 individuals, discovering that variations in the volumes of key brain regions are heritable and identified 48 genetic loci linked to these volumes, with 40 being previously unknown.
- The identified genes are connected to various biological processes, suggesting they could be crucial for understanding brain development, neurological disorders, and possible drug targets.
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
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